Cancer is a complex disease where multiple genetic and environmental factors contribute to risk. Its onset and progression depends on the combination of a series of genetic disruptions rather than on ...
High levels of a polyubiquinated form of phosphatase and tensin homolog (PTEN) were associated with an almost four-fold higher risk of a 40% decline in kidney function in a cohort of American Indians ...
Transcriptomics in Tumor and Normal Lung Tissues Identify Patients With Early-Stage Non–Small-Cell Lung Cancer With High Risk of Postsurgery Recurrence Who May Benefit From Adjuvant Therapies PTEN ...
A lipid-rich and hypoxia tumor microenvironment elevates O-GlcNAc transferase (OGT) expression, catalyzing O-GlcNAcylation of the tumor suppressor PTEN. Specifically, O-GlcNAcylation of PTEN in T382 ...
PTEN is a tumor suppressor protein with potential therapeutic applications in cancer treatment. The research aims to explore the efficacy of CNTs as a delivery system for PTEN variants and assess ...
Mdr1 gene expression as a marker of treatment response in non-small cell lung cancer (NSCLC). Background: Suppressor gene PTEN with phosphatase activity that is mutated in different tumors is located ...
PTEN is a tumour suppressor that may act by de-phosphorylating another signaling molecule, phosphatidyl inositol (PI) 3-kinase. In the November 6 Proceedings of the National Academy of Science, Javor ...
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